Treatment options for congenital heart disease are limited by the relative inability of mature cardiac muscle cells (cardiomyocytes) to generate new cardiomyocytes through proliferation after birth.

Chromatin bridges are strands of incompletely segregated DNA connecting the anaphase poles or daughter nuclei. If unresolved, chromatin bridges can break in cytokinesis leading to micronuclei ...

Polarization of a cell refers to the loss of symmetry that most cells undergo in response to external or internal signals. Some of the mechanisms for initiating and transducing polarity are shared by ...

The dedicator of cytokinesis 10 (DOCK10) gene has been identified as a key driver of abnormal insulin secretion in ...

Cytokinesis is the physical separation of two cells that occurs after the completion of mitosis. The mechanism underlying it is very complex. Until recently, the processes that lead to cleavage furrow ...

How does the cell organize multi-step cytokinetic processes to successfully separate cells after division? The final step in cell division is cytokinesis, where the cytoplasm divides into two after ...

This study, led by Dr. Panpan Jiang and collaborators at Tongji Medical College, explores the critical role of the Dedicator of Cytokinesis 8 (DOCK8) gene in the differentiation of helper T cells, ...

Cytokinesis — the final stage in eukaryotic cell division — is achieved by the constriction of an actomyosin-based contractile ring and its associated plasma membrane, partitioning the cytoplasm into ...

As cell biologists, Université de Montréal professor Greg FitzHarris and his Ph.D. student Lia Paim are very interested in fertility and what happens inside the eggs and embryos of the mice they study ...