Nature

Defects in antigen processing and presentation: mechanisms, immune evasion and implications for cancer vaccine development

Cancer immunotherapy approaches that induce or amplify endogenous antitumour T cell responses require the presentation of tumour-specific antigens by human leukocyte antigen (HLA) molecules on the ...
Nature

Optimization of THP-1-CAR monocytes utilizing CD32a signaling phagocytosis for antigen-specific T cell activation

The landscape of chimeric antigen receptor (CAR)-based cell therapies is rapidly expanding, encompassing diverse immune cell platforms such as T cells, natural killer (NK) cells, and macrophages 1,2.

New Immune System Discovery Could Help Beat a Sneaky Cancer Cell Trick

Immunotherapies – treatments that aim to make the body's natural immune system more effective – are becoming more widely used ...
Medical Xpress

Immune cell homing hydrogel-based platform captures dendritic cells to process mRNA from cancer vaccines

A research team led by Cancer Center at Illinois (CCIL) member Hua Wang has published new research detailing a new mRNA cancer vaccine platform. The study introduces an immune cell homing ...
Frontiers

B cells, natural antibodies, and humoral rejection in kidney transplantation: innate immunity to donor-specific alloresponses

Antibody-mediated rejection (ABMR) remains the leading immunological cause of kidney allograft loss, yet its humoral origins are incompletely understood.